Question:
Which of the following statements is correct for use in diagnostics and therapeutics?
Which of the following statements is correct for use in diagnostics and therapeutics?
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Monoclonal antibodies are industrially manufactured using Hybridoma Technology, developed by Georges Köhler and César Milstein in 1975, which fuses antibody-producing splenic B-cells with immortal myeloma cancer cells.
Updated On: Jun 19, 2026
- Monoclonal antibodies are preferred over polyclonal antibodies.
- Antibiotics are preferred over antibodies.
- Antibodies are not used at all.
- Only polyclonal antibodies are used.
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The Correct Option is A
Solution and Explanation
Step 1: Concept
Antibodies are critical biological agents used in modern molecular diagnostics (ELISA, Western blot, immunohistochemistry) and therapeutics (immunotherapy, targeted drug delivery).
Step 2: Monoclonal vs Polyclonal Antibodies
- Polyclonal antibodies are a heterogeneous mixture of antibodies secreted by different B-cell lineages that recognize multiple distinct epitopes on a single antigen. Their composition varies between batches, risking non-specific cross-reactivity.
- Monoclonal antibodies (mAbs) are identical antibodies produced by a single clone of hybridoma cells. They target a single, specific epitope with high affinity. They provide absolute specificity, batch-to-batch consistency, and minimized background cross-reactivity.
Step 3: Diagnostic and Therapeutic Preference
Because of their high specificity and consistent manufacturing standards, mAbs are significantly preferred over polyclonal antibodies in medical diagnostics and targeted cancer therapies.
Step 4: Conclusion
This directly supports the statement in option (A). Final Answer: (A)
Antibodies are critical biological agents used in modern molecular diagnostics (ELISA, Western blot, immunohistochemistry) and therapeutics (immunotherapy, targeted drug delivery).
Step 2: Monoclonal vs Polyclonal Antibodies
- Polyclonal antibodies are a heterogeneous mixture of antibodies secreted by different B-cell lineages that recognize multiple distinct epitopes on a single antigen. Their composition varies between batches, risking non-specific cross-reactivity.
- Monoclonal antibodies (mAbs) are identical antibodies produced by a single clone of hybridoma cells. They target a single, specific epitope with high affinity. They provide absolute specificity, batch-to-batch consistency, and minimized background cross-reactivity.
Step 3: Diagnostic and Therapeutic Preference
Because of their high specificity and consistent manufacturing standards, mAbs are significantly preferred over polyclonal antibodies in medical diagnostics and targeted cancer therapies.
Step 4: Conclusion
This directly supports the statement in option (A). Final Answer: (A)
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