Step 1: Understanding the Concept:
Mastitis is an inflammatory condition of the mammary gland that impairs secretory tissue function and increases the permeability of the blood-milk barrier.
Step 2: Detailed Explanation:
During mastitis, the inflammatory response alters milk composition in two ways:
1. Decreased Synthesis: The damaged mammary epithelial cells lose their synthetic capacity. Consequently, the concentrations of milk-specific constituents synthesized in the udder, such as lactose, casein, and fat, decrease significantly.
2. Increased Permeability: The tight junctions between secretory cells break down, allowing blood constituents to leak into milk. This leads to a marked increase in chloride, sodium, immunoglobulins (whey proteins), and somatic cells (leukocytes).
Thus, among the options, Lactose is the constituent that shows a significant reduction.
Step 3: Final Answer
Lactose is the milk constituent that is significantly reduced during subclinical mastitis.