Question:
Which of the following choline esters is hydrolyzed by butyl choline esterase:
Which of the following choline esters is hydrolyzed by butyl choline esterase:
Show Hint
Carbamates like Bethanechol and Carbachol are "Cholinesterase-proof"—they are not hydrolyzed by these enzymes.
Updated On: May 28, 2026
- Methacholine
- Bethanechol
- Carbachol
- Acetylcholine
Show Solution
Verified By Collegedunia
The Correct Option is D
Solution and Explanation
Step 1: Concept
Cholinesterases are enzymes that hydrolyze choline esters. There are two main types: Acetylcholinesterase (True) and Butyrylcholinesterase (Pseudo).
Step 2: Meaning
Butyrylcholinesterase is a non-specific enzyme found in plasma and the liver that can hydrolyze various esters, including endogenous acetylcholine.
Step 3: Analysis
Methacholine is hydrolyzed almost exclusively by true cholinesterase. Bethanechol and Carbachol are resistant to hydrolysis by both types of cholinesterases due to their carbamate structure. Acetylcholine is the primary natural substrate hydrolyzed by both enzymes.
Step 4: Conclusion
Among the given options, only Acetylcholine is significantly hydrolyzed by butyl (butyryl) choline esterase.
Final Answer: (D)
Cholinesterases are enzymes that hydrolyze choline esters. There are two main types: Acetylcholinesterase (True) and Butyrylcholinesterase (Pseudo).
Step 2: Meaning
Butyrylcholinesterase is a non-specific enzyme found in plasma and the liver that can hydrolyze various esters, including endogenous acetylcholine.
Step 3: Analysis
Methacholine is hydrolyzed almost exclusively by true cholinesterase. Bethanechol and Carbachol are resistant to hydrolysis by both types of cholinesterases due to their carbamate structure. Acetylcholine is the primary natural substrate hydrolyzed by both enzymes.
Step 4: Conclusion
Among the given options, only Acetylcholine is significantly hydrolyzed by butyl (butyryl) choline esterase.
Final Answer: (D)
Was this answer helpful?
0
0
Top CUET PG Pharmacy Questions
- Give below are two statements: One is labelled as Assertion A and the other is labelled as Reason R:
Assertion A: The presence of molecular forces produces a tendancy for individual solid particles to stick to each other and to other surface.
Reason R: Adhesion and cohesion can be considered as two aspects of particle aggregation.
In the light of the above statements, choose the most appropriate answer from the options given below: - Give below are two statements: One is labelled as Assertion A and the other is labelled as Reason R:
Assertion A: Immunoelectrophoresis or RIA is the best method for the quantification of IgE.
Reason R: Ordinary electrophoresis does not identify the subgroups of immunoglobulins IgG, IgA, IgM. IgE.
In the light of the above statements, choose the most appropriate answer from the options given below : - Give below are two statements: One is labelled as Assertion A and the other is labelled as Reason R:
Assertion A: The modified Noyes - Whitney equation states that larger the surface area of a drug, higher is the dissolution rate.
Reason R: the surface area increases with decreasing particle size.
In the light of the above statements, choose the most appropriate answer from the options given below - Give below are two statements: One is labelled as Assertion A and the other is labelled as Reason R:
Assertion A: Haloperidol is a preferred drug for acute schizophrenia and Huntington's disease.
Reason R: Parenteral administration by intramuscular route is possible in acute cases
In the light of the above statements, choose the most appropriate answer from the options given below: - Match List I with List II
List I
(Oral anti-diabetic Agents)List II
(Mechanism of Action)A. Voglibose I. AMP Activator B. Metformin II. K Channel blockers C. Tolbutamide III. \(\alpha\)-glucosidase Inhibitor D. Pioglitazone IV. PPAR-\(\gamma\) (gamma) activators
Choose the correct answer from the options given below:
View More Questions
Top CUET PG Pharmacology Questions
- Which of the following drugs is a selective serotonin reuptake inhibitor (SSRI)?
- What is the mechanism of action for the drug Omeprazole?
- Which vitamin is essential for the synthesis of blood clotting factors?
- The proper sequence of phenomenon in percutaneous absorption via trans follicular route is:
- Match the LIST-I (Rate limiting step) with LIST-II (Drugs) in absorption: [H] {|l|l|} \multicolumn{1}{|c|}{LIST-I & \multicolumn{1}{c|}{LIST-II
\multicolumn{1}{|c|}{Rate limiting step & \multicolumn{1}{c|}{Drugs
A. Gastric emptying time & I. Insulin
B. Dissolution & II. Diltiazem
C. Permeability & III. Taxol
D. Case by case & IV. Nifedipine
View More Questions
Top CUET PG Questions
- Given below are two statements:
Statement I: For Plato the meaning of the word 'Justice' is basically a conception in the mind only.
Statement II: For Plato the meaning of the word 'Justice' is fixed, mind-independently
In the light of the above statements, choose the correct answer from the options given below: - What is the electron count of OS6CO182-?
- XeF4 hydrolysis gives A + B, HF, and Oxygen. Find A and B
- What is more basic in pyrol and pyridine?
- Hydrolysis of Al2C3, Be2?
View More Questions