Question:
The proper sequence of phenomenon in percutaneous absorption via trans follicular route is:
The proper sequence of phenomenon in percutaneous absorption via trans follicular route is:
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Follicular absorption sequence: Gland $\rightarrow$ Partition $\rightarrow$ Epidermis $\rightarrow$ Dermis.
Updated On: May 28, 2026
- A, C, D, B
- A, C, B, D
- A, B, C, D
- B, A, C, D
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The Correct Option is B
Solution and Explanation
Step 1: Concept
Percutaneous absorption via the trans-follicular route bypasses the stratum corneum by entering through hair follicles and associated glands.
Step 2: Meaning
The stages include: A. Partitioning into sebaceous gland , B. Diffusion through viable epidermis , C. Partitioning into viable epidermis , and D. Diffusion through upper dermis.
Step 3: Analysis
The drug first enters the sebaceous gland (A) , then partitions into the surrounding viable epidermis (C). It then diffuses through the layers of the viable epidermis (B) before reaching the upper dermis (D) for systemic uptake.
Step 4: Conclusion
The logical physiological sequence is A-C-B-D.
Final Answer: (B)
Percutaneous absorption via the trans-follicular route bypasses the stratum corneum by entering through hair follicles and associated glands.
Step 2: Meaning
The stages include: A. Partitioning into sebaceous gland , B. Diffusion through viable epidermis , C. Partitioning into viable epidermis , and D. Diffusion through upper dermis.
Step 3: Analysis
The drug first enters the sebaceous gland (A) , then partitions into the surrounding viable epidermis (C). It then diffuses through the layers of the viable epidermis (B) before reaching the upper dermis (D) for systemic uptake.
Step 4: Conclusion
The logical physiological sequence is A-C-B-D.
Final Answer: (B)
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