Question

Which of the following drugs is a selective serotonin reuptake inhibitor (SSRI)?

• A. Fluoxetine
• B. Amitriptyline
• C. Haloperidol
• D. Diazepam

Hint:

Common \textbf{SSRIs} to remember for exams:

• \textbf{Fluoxetine}
• \textbf{Sertraline}
• \textbf{Paroxetine}
• \textbf{Citalopram}
• \textbf{Escitalopram}

Mnemonic: \textbf{“FSPCE”} (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram).

Answer 1

The Correct Option is A

Concept: Selective Serotonin Reuptake Inhibitors (SSRIs) are a class of antidepressant drugs commonly used to treat mental health disorders such as depression, anxiety disorders, obsessive–compulsive disorder (OCD), and panic disorders. SSRIs work by inhibiting the reuptake of serotonin (5-HT) in the brain. Normally, serotonin released into the synaptic cleft is reabsorbed back into the presynaptic neuron. SSRIs block this reuptake process, thereby increasing the availability of serotonin in the synaptic space. This enhanced serotonin activity improves mood and emotional stability. Common examples of SSRIs include:

• Fluoxetine
• Sertraline
• Paroxetine
• Citalopram
• Escitalopram

Step 1: Understanding the mechanism of SSRIs.
SSRIs selectively inhibit the serotonin transporter responsible for reuptake. As a result:

• Serotonin concentration in the synaptic cleft increases.
• Neurotransmission of serotonin is prolonged.
• Symptoms of depression and anxiety are reduced.

Because of their selectivity, SSRIs generally produce fewer side effects compared with older antidepressants.
Step 2: Identifying the SSRI among the given drugs.

• Fluoxetine: A well-known SSRI antidepressant used for depression, OCD, and anxiety disorders.
• Amitriptyline: A tricyclic antidepressant (TCA), not an SSRI.
• Haloperidol: A typical antipsychotic used in schizophrenia.
• Diazepam: A benzodiazepine used as an anxiolytic and sedative.

Thus, the drug belonging to the SSRI class is Fluoxetine.
Step 3: Conclusion.
Since Fluoxetine selectively inhibits serotonin reuptake and is widely used as an antidepressant, the correct answer is: \[ \text{Fluoxetine} \]