Question

What is correct sequence of elimination half life of following calcium channel blockers in increasing order?

• A. D, A, C, B
• B. C, B, A, D
• C. A, B, C, D
• D. B, D, A, C

Hint:

Amlodipine is the "long-acting king" of CCBs; Clevidipine is the "ultra-fast" IV version.

Answer 1

The Correct Option is B

Step 1: Concept
Elimination half-life ($t_{1/2}$) is the time required for the concentration of a drug in the body to be reduced by half.

Step 2: Meaning
Dihydropyridine calcium channel blockers vary significantly in their duration of action.

Step 3: Analysis
Clevidipine (C) is ultra-short acting ($t_{1/2} \approx 2$ mins). Isradipine (B) has a $t_{1/2}$ of about 8 hours. Felodipine (A) has an effective $t_{1/2}$ of 11–16 hours. Amlodipine (D) is unique for its exceptionally long $t_{1/2}$ of 30–50 hours.

Step 4: Conclusion
The increasing order is Clevidipine (C) $<$ Isradipine (B) $<$ Felodipine (A) $<$ Amlodipine (D).

Final Answer: (B)