Question:
The stop codons lead to termination of translation because:
The stop codons lead to termination of translation because:
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Stop Codons = "Nonsense" codons because no tRNA matches them.
Updated On: May 14, 2026
- there are no tRNAs corresponding to stop codons.
- the corresponding tRNA do not have an amino acid.
- the corresponding tRNA cannot bind to ribosome binding site.
- stop codon codes for pseudo amino acid.
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The Correct Option is A
Solution and Explanation
Step 1: Concept
Translation termination occurs at the A-site of the ribosome when a stop codon is encountered.
Step 2: Meaning
The three stop codons are UAA, UAG, and UGA.
Step 3: Analysis
Normally, an aminoacyl-tRNA enters the A-site to match a codon. However, no tRNAs possess anticodons complementary to the stop codons. Instead, proteins called "Release Factors" (RFs) recognize these codons and trigger the hydrolysis of the finished polypeptide from the P-site tRNA.
Step 4: Conclusion
The lack of cognate tRNAs allows release factors to bind and terminate the process. Final Answer: (A)
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