Question:
The difference between a cosmid and a plasmid is the presence of which one of the following additional features in a cosmid?
The difference between a cosmid and a plasmid is the presence of which one of the following additional features in a cosmid?
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Cosmid = Cos site + Plasmid. (Cos site comes from Lambda phage).
Updated On: May 14, 2026
- a $\lambda$ phage DNA sequence that includes a cos site
- an M13 phage DNA sequence that includes a cos site
- a T4 phage DNA sequence that includes a cos site
- a T7 phage DNA sequence that includes a cos site
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The Correct Option is A
Solution and Explanation
Step 1: Concept
A cosmid is a hybrid cloning vector that combines properties of a plasmid and a bacteriophage.
Step 2: Meaning
It contains the origin of replication ($ori$) and antibiotic resistance of a plasmid, plus the cohesive ($cos$) sites from the Lambda ($\lambda$) phage.
Step 3: Reasoning
The $cos$ site allows the DNA to be packaged into Lambda phage heads, enabling the cloning of much larger fragments than a standard plasmid.
Step 4: Conclusion
The distinguishing feature is the $\lambda$ phage $cos$ site. Final Answer: (A)
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