Question:
The rate limiting step for the absorption of controlled release tablet is the:
The rate limiting step for the absorption of controlled release tablet is the:
Updated On: Jul 14, 2026
- Metabolism of the drug
- Excretion of the drug
- Dissolution of the drug
- Distribution of the drug
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The Correct Option is C
Approach Solution - 1
The correct option is (C): Dissolution of the drug.
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Approach Solution -2
The question asks which pharmacokinetic step controls how fast a controlled release tablet's drug becomes available for absorption. Let's check each option against where it actually sits in the drug's journey through the body.
- Metabolism of the drug: Metabolism happens after the drug has already been absorbed into the body, so it cannot be the step limiting how fast the drug gets into the bloodstream from a tablet still sitting in the gut.
- Excretion of the drug: Excretion removes drug from the body after it has been absorbed, distributed, and often metabolized, so it plays no part in controlling the initial rate at which drug becomes available for absorption.
- Dissolution of the drug: A controlled release tablet is deliberately built with a matrix or coating that slows how fast drug particles dissolve into the surrounding fluid. Since a drug cannot cross the gut wall until it is dissolved, this deliberately slowed dissolution step becomes the slowest, and therefore rate-limiting, step in the whole absorption process.
- Distribution of the drug: Distribution describes how the drug moves from blood into tissues once it is already absorbed, a step that comes after absorption and has no bearing on what happens inside the gut before the drug enters circulation.
Only dissolution happens before absorption and only dissolution is the step deliberately engineered to be slow in a controlled release formulation.
The correct answer is Dissolution of the drug.
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