Question:
Select the equation that gives the rate of drug dissolution from a tablet
Select the equation that gives the rate of drug dissolution from a tablet
Updated On: Feb 9, 2026
- Fick's law
- Henderson Hasselbach equation
- Noyes Whitney Equation
- Michaelis Menton equation
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The Correct Option is C
Solution and Explanation
To determine the rate of drug dissolution from a tablet, we rely on the Noyes-Whitney Equation. This equation is specifically designed to describe the dissolution rate of solid substances into a solvent, which is a crucial step in the pharmacokinetics of oral dosage forms like tablets.
Let's examine and understand why the Noyes-Whitney equation is the correct choice and how it contrasts with the other options:
- The Noyes-Whitney Equation is expressed as:
\[\frac{dC}{dt} = \frac{DA(C_s - C)}{L}\]
Where:
- \( \frac{dC}{dt} \) is the rate of dissolution.
- \( D \) is the diffusion coefficient.
- \( A \) is the surface area of the solid.
- \( C_s \) is the saturated concentration of the drug in the solvent.
- \( C \) is the concentration of the drug in the solvent at time \( t \).
- \( L \) is the thickness of the diffusion layer.
- Fick's Law describes the diffusion process, particularly focusing on the rate of diffusion across a concentration gradient. While it relates to how substances move, it does not specifically apply to the dissolution rate of a tablet.
- The Henderson-Hasselbalch Equation is used to estimate the pH of a buffer solution. It relates to the dissociation of acids/bases in a solution and not the dissolution of a substance into a solvent.
- The Michaelis-Menten Equation describes the rate of enzymatic reactions and is not related to the dissolution process of a drug from a tablet.
By understanding the context and design purpose of the Noyes-Whitney equation, it is evident that it primarily addresses the dissolution rate of drugs from tablets, making it the correct option for this question.
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