Step 1: Concept
The radius $r$ is the distance between the center $(h, k)$ and any point $(x_1, y_1)$ on the circle.
Step 2: Meaning
Calculate $r^2$ using the distance formula: $r^{2} = (x_1 - h)^{2} + (y_1 - k)^{2}$.
Step 3: Analysis
$r^{2} = (3 - 2)^{2} + (6 - (-1))^{2} = 1^{2} + 7^{2} = 1 + 49 = 50$. The circle equation is $(x - 2)^{2} + (y + 1)^{2} = 50$.
Step 4: Conclusion
Expanding gives $x^{2} - 4x + 4 + y^{2} + 2y + 1 = 50$, which simplifies to $x^{2} + y^{2} - 4x + 2y - 45 = 0$.
Final Answer: (D)