Question

The degradation of orally administered drug by the liver before entering into systemic circulation is referred as

• A. First pass metabolism
• B. Phase-i metabolism
• C. Phase-ii metabolism
• D. Biotransformation

Hint:

First Pass = The liver gets the "first pass" at the drug before the heart sends it to the body.

Answer 1

The Correct Option is A

Step 1: Concept
When a drug is absorbed from the gastrointestinal tract, it travels through the portal vein to the liver before reaching the rest of the body.

Step 2: Meaning
The liver is the primary site of drug metabolism and may significantly reduce the amount of active drug that survives this first journey.

Step 3: Analysis
While Phase-I and Phase-II are types of biotransformation reactions, the specific phenomenon of metabolism occurring before the drug reaches systemic circulation is the "first pass".

Step 4: Conclusion
This initial hepatic degradation is universally known as the first-pass effect or first-pass metabolism.

Final Answer: (A)