Question

The cells within the small intestine crypts that secret mucus are

• A. Crypt enterocytes
• B. Goblet cells
• C. Enteroendocrine cells
• D. Paneth cells

Hint:

Goblet cells derive their name from their unique goblet-like shape, which is caused by the accumulation of mucin granules in their apical cytoplasm that compresses the nucleus toward the base.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
The mucosal lining of the small intestine is folded into villi and crypts of Lieberkühn.
The intestinal epithelium contains several specialized cell types that coordinate digestion, absorption, secretion, and local defense.

Step 2: Detailed Explanation:
Let us review the functions of the cell types located within the intestinal crypts:
Enterocytes: The most abundant epithelial cells, primarily responsible for nutrient absorption and secretion of water and electrolytes.
Goblet Cells: Specialized, mucin-producing epithelial cells scattered throughout the villi and crypts.
They synthesize and secrete high-molecular-weight glycoproteins known as mucins.
These mucins hydrate to form mucus, which lubricates the luminal surface, protects the mucosa from mechanical friction and enzymatic digestion, and acts as a physical barrier against bacterial invasion.
Enteroendocrine Cells: Endocrine cells that secrete gastrointestinal hormones (such as cholecystokinin, secretin, and GIP) into the bloodstream to regulate digestive function.
Paneth Cells: Located at the base of the crypts, these cells secrete antimicrobial peptides (like lysozyme and defensins) to regulate the gut microbiota.
Therefore, Goblet cells are the cells responsible for secreting mucus.

Step 3: Final Answer:
The mucus-secreting cells within the small intestine crypts are the Goblet cells.