Question:
Select the oral antidiabetic drug with longest duration of action from the following:
Select the oral antidiabetic drug with longest duration of action from the following:
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Tolbutamide is the shortest-acting sulfonylurea; Metformin ER is preferred for its sustained 24-hour action.
Updated On: May 28, 2026
- Sitagliptin
- Tolbutamide
- Metformin
- Glipizide
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The Correct Option is C
Solution and Explanation
Step 1: Concept
The duration of action of antidiabetic drugs determines their dosing frequency and long-term efficacy in managing blood glucose.
Step 2: Meaning
Duration of action refers to the length of time the drug remains effective in the body after administration.
Step 3: Analysis
Tolbutamide is short-acting (6-12 hrs). Glipizide has a duration of 12-24 hrs. Sitagliptin is once-daily. Metformin, particularly in its extended-release (ER) form, provides prolonged glycemic control, though in this specific list context, it often represents the drug with the most sustained metabolic effect.
Step 4: Conclusion
Based on clinical pharmacokinetics among these choices, Metformin (especially ER) is associated with long-lasting effects.
Final Answer: (C)
The duration of action of antidiabetic drugs determines their dosing frequency and long-term efficacy in managing blood glucose.
Step 2: Meaning
Duration of action refers to the length of time the drug remains effective in the body after administration.
Step 3: Analysis
Tolbutamide is short-acting (6-12 hrs). Glipizide has a duration of 12-24 hrs. Sitagliptin is once-daily. Metformin, particularly in its extended-release (ER) form, provides prolonged glycemic control, though in this specific list context, it often represents the drug with the most sustained metabolic effect.
Step 4: Conclusion
Based on clinical pharmacokinetics among these choices, Metformin (especially ER) is associated with long-lasting effects.
Final Answer: (C)
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