Question:
Match List I with List II List I-Tablet Diluents List II-properties A Lactose I 2 to 4 percent of moisture B Mannitol II Maillard reaction C Calcium phosphate III Negative heat of solution D Specially dried starch IV Contraindicated for Tetracycline
Choose the correct answer from the options given below:
Match List I with List II
| List I-Tablet Diluents | List II-properties | ||
| A | Lactose | I | 2 to 4 percent of moisture |
| B | Mannitol | II | Maillard reaction |
| C | Calcium phosphate | III | Negative heat of solution |
| D | Specially dried starch | IV | Contraindicated for Tetracycline |
Choose the correct answer from the options given below:
Updated On: Feb 24, 2026
- (A)-(III), (B)-(IV), (C)-(I), (D)-(II)
- (A)-(II). (B)-(IV), (C)-(I), (D)-(III)
- (A)-(III), (B)-(I). (C)-(IV), (D)-(II
- (A)-(II), (B)-(III), (C)-(IV), (D)-(I)
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The Correct Option is D
Solution and Explanation
To solve the problem, we need to match each item in List I with its corresponding property in List II based on our knowledge of pharmaceutical excipients (tablet diluents) and their chemical characteristics.
- Lactose: Lactose is known to participate in the Maillard reaction when it comes in contact with amine-containing drugs. The Maillard reaction is a chemical reaction between amino acids and reducing sugars that gives browned foods their distinctive flavor. Therefore, the correct match for lactose is II - Maillard reaction.
- Mannitol: Mannitol exhibits a negative heat of solution, which means it absorbs heat, giving a cooling sensation in the mouth. This is a key property of mannitol, making it suitable for chewing gum and as a sweetener. Thus, the correct match for mannitol is III - Negative heat of solution.
- Calcium phosphate: Calcium phosphate is often used as a diluent in tablets, but it is known to be contraindicated with tetracycline antibiotics. This is because it can bind with tetracycline and interfere with the absorption of the drug. Hence, the correct match for calcium phosphate is IV - Contraindicated for Tetracycline.
- Specially dried starch: Dried starch generally possesses 2 to 4 percent of moisture, which is controlled to prevent caking or sticking in the tablet. Therefore, the correct match for specially dried starch is I - 2 to 4 percent of moisture.
Thus, the correct matching is:
| (A) | - | (II) |
| (B) | - | (III) |
| (C) | - | (IV) |
| (D) | - | (I) |
Therefore, the correct answer is: (A)-(II), (B)-(III), (C)-(IV), (D)-(I).
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