Question

Match List I with List II

	List I-Tablet Diluents		List II-properties
A	Lactose	I	2 to 4 percent of moisture
B	Mannitol	II	Maillard reaction
C	Calcium phosphate	III	Negative heat of solution
D	Specially dried starch	IV	Contraindicated for Tetracycline

Choose the correct answer from the options given below:

• A. (A)-(III), (B)-(IV), (C)-(I), (D)-(II)
• B. (A)-(II). (B)-(IV), (C)-(I), (D)-(III)
• C. (A)-(III), (B)-(I). (C)-(IV), (D)-(II
• D. (A)-(II), (B)-(III), (C)-(IV), (D)-(I)

Answer 1

The Correct Option is D

To solve the problem, we need to match each item in List I with its corresponding property in List II based on our knowledge of pharmaceutical excipients (tablet diluents) and their chemical characteristics. 

1. Lactose: Lactose is known to participate in the Maillard reaction when it comes in contact with amine-containing drugs. The Maillard reaction is a chemical reaction between amino acids and reducing sugars that gives browned foods their distinctive flavor. Therefore, the correct match for lactose is II - Maillard reaction.
2. Mannitol: Mannitol exhibits a negative heat of solution, which means it absorbs heat, giving a cooling sensation in the mouth. This is a key property of mannitol, making it suitable for chewing gum and as a sweetener. Thus, the correct match for mannitol is III - Negative heat of solution.
3. Calcium phosphate: Calcium phosphate is often used as a diluent in tablets, but it is known to be contraindicated with tetracycline antibiotics. This is because it can bind with tetracycline and interfere with the absorption of the drug. Hence, the correct match for calcium phosphate is IV - Contraindicated for Tetracycline.
4. Specially dried starch: Dried starch generally possesses 2 to 4 percent of moisture, which is controlled to prevent caking or sticking in the tablet. Therefore, the correct match for specially dried starch is I - 2 to 4 percent of moisture.

Thus, the correct matching is:

(A)	-	(II)
(B)	-	(III)
(C)	-	(IV)
(D)	-	(I)

Therefore, the correct answer is: (A)-(II), (B)-(III), (C)-(IV), (D)-(I).