Question:
Select correct secondary messenger pathway of \(G_{s}\) protein couple receptor:
Select correct secondary messenger pathway of \(G_{s}\) protein couple receptor:
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$G_{s}$ = Stimulates cAMP; $G_{i}$ = Inhibits cAMP; $G_{q}$ = Stimulates Phospholipase C.
Updated On: May 28, 2026
- Increase cyclic AMP
- Decrease cyclic AMP
- Increase phospholipase
- Increase cyclic GMP
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The Correct Option is A
Solution and Explanation
Step 1: Concept
G-protein-coupled receptors (GPCRs) use different G-protein subtypes to trigger specific intracellular signaling cascades.
Step 2: Meaning
The subscript "s" in $G_{s}$ stands for "stimulatory".
Step 3: Analysis
When activated, $G_{s}$ stimulates the enzyme adenylyl cyclase. This enzyme then catalyzes the conversion of ATP to cyclic AMP (cAMP), leading to an increase in intracellular cAMP levels.
Step 4: Conclusion
The correct pathway for $G_{s}$ is the increase of cyclic AMP.
Final Answer: (A)
G-protein-coupled receptors (GPCRs) use different G-protein subtypes to trigger specific intracellular signaling cascades.
Step 2: Meaning
The subscript "s" in $G_{s}$ stands for "stimulatory".
Step 3: Analysis
When activated, $G_{s}$ stimulates the enzyme adenylyl cyclase. This enzyme then catalyzes the conversion of ATP to cyclic AMP (cAMP), leading to an increase in intracellular cAMP levels.
Step 4: Conclusion
The correct pathway for $G_{s}$ is the increase of cyclic AMP.
Final Answer: (A)
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