Question

route of drug administration achieves 100% bioavailability.

• A. Intramuscular
• B. Intravenous
• C. Oral
• D. Intraperitoneal

Hint:

IV = Immediate Victory over absorption barriers; result is 100% bioavailability.

Answer 1

The Correct Option is B

Step 1: Concept
Bioavailability is the fraction of an administered dose of unchanged drug that reaches the systemic circulation.

Step 2: Meaning
A bioavailability of 100% means the entire dose enters the bloodstream immediately without any loss.

Step 3: Analysis
Oral drugs undergo first-pass metabolism in the liver, reducing bioavailability. Intramuscular and intraperitoneal routes require absorption across membranes, which may be incomplete. The intravenous (IV) route bypasses all absorption barriers by injecting the drug directly into the vein.

Step 4: Conclusion
Therefore, the intravenous route is the only one that by definition achieves 100% bioavailability.

Final Answer: (B)