Name a blood related autosomal Mendelian disorder. Why is it called as Mendelian disorder? How is the disorder transmitted from parents to offspring?
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Solution and Explanation
- Thalassemia is a blood-related autosomal Mendelian disorder.
- It is called a Mendelian disorder because it follows the inheritance patterns first proposed by Gregor Mendel, involving a single gene mutation.
- Thalassemia is caused by mutations in the gene responsible for haemoglobin chain production.
- The disorder is transmitted from parents to offspring when both parents are carriers (heterozygous), with a 25% chance of the child being affected if both defective alleles are inherited.
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Study the diagram above and answer the following questions:
(a) How many alleles are involved in blood grouping?(b) A person having 'AB' blood group has both dominant alleles. What is this inheritance type called?
(c) A man with 'A' blood group marries a woman with 'B' blood group. Can they have a child with 'O' blood group? Explain with the help of a cross.
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- (a) A man with blood group ‘A’ marries a woman with blood group ‘AB’. The first child born to them has blood group ‘B’. Work out a cross to find the genotype of the father. Give the possible blood groups and their genotypes of the children that could be born to this couple. (Use a Punnet square).
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\[ \begin{array}{|c|c|} \hline \textbf{Bioactive Substance} & \textbf{Role} \\ \hline \text{Statin} & \text{Removal of oil stains} \\ \text{Cyclosporin A} & \text{Removal of clots from blood vessels} \\ \text{Streptokinase} & \text{Lowering of blood cholesterol} \\ \text{Lipase} & \text{Immunosuppressive agent} \\ \hline \end{array} \]
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