Question

Match List - I with List - II. Lysosomal enzymes and the substrates on which they act. 

Choose the correct answer from the options given below : 
 

• A. A-I, B-II, C-III, D-IV
• B. A-IV, B-III, C-I, D-II
• C. A-IV, B-II, C-I, D-III
• D. A-I, B-II, C-IV, D-III

Hint:

Enzyme nomenclature typically takes the name of the substrate and adds the suffix "-ase".
Ribonucleic acid (RNA) + ase = Ribonuclease. Glycoside + ase = Glycosidase.

Answer 1

The Correct Option is C

Step 1: Concept:
The question asks us to accurately match various hydrolytic lysosomal enzymes with their specific biological substrates.

Step 2: Step-by-step Explanation:

• A. Phosphatase: Phosphatases are enzymes that cleave phosphate groups from their substrates by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group. Therefore, their specific substrate is Phosphate esters.
Thus, A matches with IV.

• B. Collagenase: This is a specialized proteolytic enzyme (protease) that breaks the peptide bonds in collagen, which is a structural protein. Therefore, its primary substrate broadly falls under Proteins.
Thus, B matches with II.

• C. Ribonuclease (RNase): This enzyme catalyzes the degradation of RNA into smaller components by cleaving the phosphodiester bonds of ribonucleotides. Therefore, its substrate is unequivocally RNA.
Thus, C matches with I.

• D. Glycosidase: Glycosidases (or glycoside hydrolases) are enzymes that catalyze the hydrolysis of glycosidic bonds in complex sugars. Their primary targets are Complex carbohydrates (like glycogen or glycoproteins).
Thus, D matches with III.

• Combining all matches: A-IV, B-II, C-I, D-III.

Step 3: Final Answer:
The matching pairs correspond to Option (C).