Question

Match List I with List II
List I (Causative Organism):
A. Staphylococcus aureus
B. E.coli O157: H7
C. Campylobacter jejuni
D. Vibrio cholera
List II (Disease/Syndrome):
I. Cholera
II. Guillain Barre Syndrome
III. Toxic Shock Syndrome
IV. Haemolytic uremic syndrome
V. Emesis
Choose the correct answer from the options given below:

• A. A - II, B - III, C - IV, D - V
• B. A - III, B - IV, C - I, D - II
• C. A - III, B - IV, C - II, D - I
• D. A - IV, B - V, C - I, D - II

Hint:

Remember the unique clinical associations: E. coli O157:H7 is the classic cause of HUS, while Campylobacter jejuni is the leading post-infectious trigger for Guillain-Barré Syndrome.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Pathogenic microorganisms produce specific virulence factors, such as enterotoxins, cytotoxins, or endotoxins, which cause distinct clinical diseases or pathological syndromes.

Step 2: Detailed Explanation:
Let us match each causative organism in List I with its respective disease/syndrome in List II:
- A. Staphylococcus aureus: This bacterium produces toxic shock syndrome toxin-1 (TSST-1), a superantigen that causes systemic immune activation, matching with Toxic Shock Syndrome (III).
- B. E. coli O157:H7: This enterohemorrhagic strain produces Shiga-like toxins that damage renal endothelial cells, leading to microangiopathic hemolytic anemia and acute kidney failure, matching with Haemolytic uremic syndrome (IV).
- C. Campylobacter jejuni: Infection with this organism can trigger an autoimmune response due to molecular mimicry between campylobacter lipooligosaccharides and human peripheral nerve myelin, leading to acute demyelinating polyneuropathy, matching with Guillain Barre Syndrome (II).
- D. Vibrio cholerae: This bacterium produces cholera toxin, which stimulates adenylate cyclase in intestinal cells, causing severe, watery diarrhea, matching with Cholera (I).
This gives the match: A-III, B-IV, C-II, D-I.

Step 3: Final Answer
The correct option is (C).