Question

Match List-I with List-II: 

List-I		List-II
(A)	Cephalosporin	(IV)	Inhibition of crosslinking of bacterial cell wall
(B)	Erythromycin	(II)	Protein synthesis inhibition by binding to 50S subunit of ribosome
(C)	Sulfonamides	(I)	Inhibition of enzyme systems
(D)	Nalidixic Acid	(III)	Inhibition of DNA synthesis

• A. \(A\text{-IV},\ B\text{-II},\ C\text{-I},\ D\text{-III}\)
• B. \(A\text{-I},\ B\text{-III},\ C\text{-IV},\ D\text{-II}\)
• C. \(A\text{-II},\ B\text{-I},\ C\text{-III},\ D\text{-IV}\)
• D. \(A\text{-III},\ B\text{-IV},\ C\text{-II},\ D\text{-I}\)

Hint:

Remember:
• Cephalosporins \(\rightarrow\) Cell wall synthesis inhibition
• Erythromycin \(\rightarrow\) 50S ribosomal inhibitor
• Sulfonamides \(\rightarrow\) Folic acid pathway inhibition
• Nalidixic acid \(\rightarrow\) DNA gyrase inhibitor

Answer 1

The Correct Option is A

Concept: Different antibiotics inhibit bacterial growth by targeting specific cellular processes such as:
• Cell wall synthesis
• Protein synthesis
• DNA synthesis
• Metabolic enzyme systems

Step 1: Matching Cephalosporin. Cephalosporins are \(\beta\)-lactam antibiotics that inhibit: \[ \text{Crosslinking of bacterial cell wall} \] by interfering with peptidoglycan synthesis. Thus: \[ A \rightarrow IV \]

Step 2: Matching Erythromycin. Erythromycin is a macrolide antibiotic that binds to: \[ 50S \text{ ribosomal subunit} \] thereby inhibiting protein synthesis. Thus: \[ B \rightarrow II \]

Step 3: Matching Sulfonamides. Sulfonamides inhibit bacterial metabolic enzyme systems involved in: \[ \text{Folic acid synthesis} \] Thus: \[ C \rightarrow I \]

Step 4: Matching Nalidixic acid. Nalidixic acid inhibits: \[ \text{DNA synthesis} \] by targeting bacterial DNA gyrase. Thus: \[ D \rightarrow III \]

Step 5: Determining the correct combination. Therefore: \[ \boxed{ A\text{-IV},\ B\text{-II},\ C\text{-I},\ D\text{-III} } \] Hence, the correct answer is: \[ \boxed{(A)\ A\text{-IV},\ B\text{-II},\ C\text{-I},\ D\text{-III}} \]