Question

How does a chromosomal disorder differ from a Mendelian disorder? Write one example for each.

Hint:

Chromosomal disorders involve issues with chromosome number or structure, while Mendelian disorders are caused by single-gene mutations.

Answer 1

Step 1: Chromosomal Disorder.
Chromosomal disorders are caused by abnormalities in the number or structure of chromosomes. An example is Down syndrome, which occurs due to an extra copy of chromosome 21 (trisomy 21).
Step 2: Mendelian Disorder.
Mendelian disorders are caused by mutations in a single gene, following Mendelian inheritance patterns. An example is Cystic Fibrosis, which is caused by a mutation in the CFTR gene and follows autosomal recessive inheritance.