Question:
Glucocorticoid possess diabetes inducing effect due to:
Glucocorticoid possess diabetes inducing effect due to:
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Glucocorticoids are "Anti-Insulin"—they stop the body from "eating" glucose, keeping blood sugar high.
Updated On: May 28, 2026
- Negative regulation of COX2
- Inhibition of hepatic glycogen synthetase enzyme
- Decrease glucose uptake and utilization in peripheral tissues
- Increased expression of POMC gene in pituitary gland
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The Correct Option is C
Solution and Explanation
Step 1: Concept
Glucocorticoids (like cortisol) have significant metabolic effects, often opposing the actions of insulin, which can lead to "steroid diabetes".
Step 2: Meaning
They promote hyperglycemia by increasing glucose production and reducing the body's ability to clear glucose from the blood.
Step 3: Analysis
Glucocorticoids stimulate gluconeogenesis in the liver. Critically, they reduce the translocation of GLUT4 transporters to the cell membrane in muscle and adipose tissue, which decreases glucose uptake and utilization.
Step 4: Conclusion
The primary mechanism for their diabetogenic effect is the reduction of glucose uptake in peripheral tissues.
Final Answer: (C)
Glucocorticoids (like cortisol) have significant metabolic effects, often opposing the actions of insulin, which can lead to "steroid diabetes".
Step 2: Meaning
They promote hyperglycemia by increasing glucose production and reducing the body's ability to clear glucose from the blood.
Step 3: Analysis
Glucocorticoids stimulate gluconeogenesis in the liver. Critically, they reduce the translocation of GLUT4 transporters to the cell membrane in muscle and adipose tissue, which decreases glucose uptake and utilization.
Step 4: Conclusion
The primary mechanism for their diabetogenic effect is the reduction of glucose uptake in peripheral tissues.
Final Answer: (C)
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