Question

Demineralization of bone resulting in softening, bending and fracture of bones, common in women who have reached menopause is called i and is caused due to ii.

• A. i: Myxoedema, ii: hyposecretion of thyroxine hormone.
• B. i: Acromegaly, ii: hyposecretion of Growth hormone.
• C. i: Osteoporosis, ii: hypersecretion of parathormone.
• D. i: Grave's disease, ii: hypersecretion of calcitonin.

Hint:

Bone rule: PTH ↑ → bone calcium ↓ → osteoporosis risk.

Answer 1

The Correct Option is C

Concept:
Bone metabolism is regulated by hormones like parathormone (PTH), calcitonin, and estrogen. Imbalance leads to bone disorders.

Step 1: Identify the condition.
• Loss of bone minerals → Weak, porous bones
• Common in post-menopausal women This condition is osteoporosis.

Step 2: Understand cause.
• Parathormone increases calcium release from bones
• Excess (hypersecretion) leads to demineralization Thus, osteoporosis is associated with hypersecretion of parathormone.

Step 3: Analyze options.
• (A) Myxoedema → Thyroid disorder $\times$
• (B) Acromegaly → GH excess, not related $\times$
• (C) Osteoporosis + hypersecretion of PTH → Correct \checkmark
• (D) Grave’s disease → Hyperthyroidism $\times$

Step 4: Conclusion. \[ \text{Osteoporosis is caused by increased parathormone activity} \]