Question

Correct Relative potency of bisphosphonates in increasing order of following drugs is:

• A. A, B, D, C
• B. B, A, C, D
• C. C, A, B, D
• D. A, C, D, B

Hint:

Zoledronate is the "Z-power" bisphosphonate—it's the most potent of the group!

Answer 1

The Correct Option is A

Step 1: Concept
Bisphosphonates are drugs used to treat osteoporosis and bone diseases. Their potency (the dose required to produce an effect) varies based on their generation and chemical structure.

Step 2: Meaning
Nitrogen-containing bisphosphonates are much more potent than non-nitrogen-containing ones.

Step 3: Analysis
Etidronate (A) is a first-generation non-nitrogen bisphosphonate with the lowest potency. Pamidronate (B) is more potent. Ibandronate (D) is highly potent. Zoledronate (C) is the most potent bisphosphonate available, typically administered only once a year.

Step 4: Conclusion
The increasing order of potency is: Etidronate (A) $<$ Pamidronate (B) $<$ Ibandronate (D) $<$ Zoledronate (C).

Final Answer: (A)