Question:
Core tablet coated with cellulose acetate phthalate has been administered to a patient. Where do you expect the drug to be released:
Core tablet coated with cellulose acetate phthalate has been administered to a patient. Where do you expect the drug to be released:
Updated On: Jul 14, 2026
- Liver
- Intestine
- Oral cavity
- Stomach
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The Correct Option is B
Approach Solution - 1
The correct option is (B): Intestine.
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Approach Solution -2
Cellulose acetate phthalate (CAP) is a classic enteric coating polymer used on tablets that should not release their drug in the stomach. The question is testing whether the reader knows how a pH-dependent coating decides where a tablet breaks open. Let's look at each site listed as an option.
- Liver: No oral coating, enteric or otherwise, is designed to release a drug directly in the liver. Drug reaches the liver only after absorption from the gut, through the portal blood supply, so this is not a release site a coating can target.
- Intestine: CAP contains free carboxylic acid (phthalate) groups that stay un-ionized and insoluble at the low pH of the stomach, so the coating stays intact there. Once the tablet moves into the small intestine, where the pH rises above about 5 to 6, these acid groups ionize, the polymer becomes soluble, and the coating dissolves away to expose the core. This is exactly the release pattern CAP is chosen for.
- Oral cavity: A tablet swallowed whole passes through the mouth in seconds, far too briefly and at the wrong pH for any coating, enteric or not, to dissolve there.
- Stomach: This is the one place CAP is specifically designed to resist. Gastric pH is typically between 1 and 3, well below the pH at which CAP's carboxyl groups ionize, so the film stays closed and protects the core from gastric fluid.
Because CAP is acid-insoluble and only dissolves once the pH climbs in the small intestine, the tablet core is released there rather than in the stomach.
The correct answer is Intestine.
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