Question:
Choose the correct antiemetic compound with NK1 receptor antagonist activity:
Choose the correct antiemetic compound with NK1 receptor antagonist activity:
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Drugs ending in "-pitant" (Aprepitant, Rolapitant) are NK1 receptor antagonists.
Updated On: May 28, 2026
- Promethazine
- Ondansetron
- Aprepitant
- Dicyclomine
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The Correct Option is C
Solution and Explanation
Step 1: Concept
Antiemetics work by blocking different receptors in the vomiting center and chemoreceptor trigger zone (CTZ). The Neurokinin-1 (NK1) receptor is a target for Substance P.
Step 2: Meaning
NK1 receptor antagonists are a class of medications primarily used to prevent chemotherapy-induced nausea and vomiting (CINV).
Step 3: Analysis
Promethazine is an H1-antagonist. Ondansetron is a 5-HT3 receptor antagonist. Dicyclomine is an anticholinergic. Aprepitant is the prototype drug that selectively blocks NK1 receptors.
Step 4: Conclusion
Aprepitant is the correct NK1 receptor antagonist.
Final Answer: (C)
Antiemetics work by blocking different receptors in the vomiting center and chemoreceptor trigger zone (CTZ). The Neurokinin-1 (NK1) receptor is a target for Substance P.
Step 2: Meaning
NK1 receptor antagonists are a class of medications primarily used to prevent chemotherapy-induced nausea and vomiting (CINV).
Step 3: Analysis
Promethazine is an H1-antagonist. Ondansetron is a 5-HT3 receptor antagonist. Dicyclomine is an anticholinergic. Aprepitant is the prototype drug that selectively blocks NK1 receptors.
Step 4: Conclusion
Aprepitant is the correct NK1 receptor antagonist.
Final Answer: (C)
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