Question:
Assertion A: Tripelannamine and methaphenilene have similar biological property.
Reason R: Because they are stereoisomers of each other.
Assertion A: Tripelannamine and methaphenilene have similar biological property.
Reason R: Because they are stereoisomers of each other.
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Pyridine and Thiophene rings are often interchangeable in drug design; this is called "Bioisosterism," not "Stereoisomerism."
Updated On: May 28, 2026
- Both A and R are correct and R is the correct explanation of A
- Both A and R are correct but R is NOT the correct explanation of A
- A is correct but R is not correct
- A is not correct but R is correct
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The Correct Option is C
Solution and Explanation
Step 1: Concept
This involves the structure-activity relationship (SAR) of ethylenediamine-class antihistamines.
Step 2: Meaning
Tripelennamine and Methaphenilene are both first-generation H1-receptor antagonists.
Step 3: Analysis
Assertion A is correct because both drugs are ethylenediamine derivatives used as antihistamines with similar pharmacological profiles. However, Reason R is incorrect because they are bioisosteres, not stereoisomers. In Methaphenilene, the benzyl group of Tripelennamine is replaced with a thenyl (thiophene) group.
Step 4: Conclusion
Since the similarity is due to bioisosterism and not stereoisomerism, A is correct but R is not.
Final Answer: (C)
This involves the structure-activity relationship (SAR) of ethylenediamine-class antihistamines.
Step 2: Meaning
Tripelennamine and Methaphenilene are both first-generation H1-receptor antagonists.
Step 3: Analysis
Assertion A is correct because both drugs are ethylenediamine derivatives used as antihistamines with similar pharmacological profiles. However, Reason R is incorrect because they are bioisosteres, not stereoisomers. In Methaphenilene, the benzyl group of Tripelennamine is replaced with a thenyl (thiophene) group.
Step 4: Conclusion
Since the similarity is due to bioisosterism and not stereoisomerism, A is correct but R is not.
Final Answer: (C)
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