Question

Assertion A: Losartan is a first line drug, comparable in efficacy to enalapril. Reason R: It is because of advantage of inducing incidence of angioedema and cough.

• A. Both A and R are correct and R is the correct explanation of A
• B. Both A and R are correct but R is NOT the correct explanation of A
• C. A is correct but R is not correct
• D. A is not correct but R is correct

Hint:

Use ARBs (Losartan) when ACE Inhibitors (Enalapril) cause that annoying dry cough!

Answer 1

The Correct Option is C

Step 1: Concept
Losartan is an Angiotensin Receptor Blocker (ARB), and Enalapril is an ACE Inhibitor. Both are used for hypertension.

Step 2: Meaning
ARBs and ACE inhibitors both act on the Renin-Angiotensin-Aldosterone System (RAAS) but at different points.

Step 3: Analysis
Assertion A is correct: Losartan is a first-line antihypertensive with efficacy similar to Enalapril. However, Reason R is fundamentally incorrect. The *advantage* of Losartan (and other ARBs) is that they *do not* cause the bradykinin accumulation that leads to dry cough and angioedema—side effects common with ACE inhibitors like Enalapril.

Step 4: Conclusion
Statement A is true, but Statement R is false because Losartan reduces, not induces, these side effects.

Final Answer: (C)