Question:
Assertion A: High ceiling diuretics have major adverse effects lead to weakness, fatigue and muscle cramps.
Reason R: They induce hypokelemia.
Assertion A: High ceiling diuretics have major adverse effects lead to weakness, fatigue and muscle cramps.
Reason R: They induce hypokelemia.
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"High ceiling" means they have a high limit for how much salt/water they can flush out.
Updated On: May 28, 2026
- Both A and R are correct and R is the correct explanation of A
- Both A and R are correct but R is NOT the correct explanation of A
- A is correct but R is not correct
- A is not correct but R is correct
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The Correct Option is A
Solution and Explanation
Step 1: Concept
High ceiling (loop) diuretics like furosemide are potent agents that inhibit the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle.
Step 2: Meaning
They cause a significant loss of water and electrolytes, including sodium and potassium.
Step 3: Analysis
Assertion A is correct: The electrolyte imbalance caused by loop diuretics often leads to muscle weakness and cramps. Reason R is the correct explanation: These drugs significantly increase potassium excretion. Low blood potassium (hypokalemia) disrupts normal muscle and nerve function, resulting in those specific symptoms.
Step 4: Conclusion
Both A and R are true, and R directly explains why the symptoms in A occur.
Final Answer: (A)
High ceiling (loop) diuretics like furosemide are potent agents that inhibit the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle.
Step 2: Meaning
They cause a significant loss of water and electrolytes, including sodium and potassium.
Step 3: Analysis
Assertion A is correct: The electrolyte imbalance caused by loop diuretics often leads to muscle weakness and cramps. Reason R is the correct explanation: These drugs significantly increase potassium excretion. Low blood potassium (hypokalemia) disrupts normal muscle and nerve function, resulting in those specific symptoms.
Step 4: Conclusion
Both A and R are true, and R directly explains why the symptoms in A occur.
Final Answer: (A)
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