Question

Assertion A: Felbamate exhibits rare occurrence of aplastic anaemia and sever hepatotoxicity. Reason R: It is associated with the formation of reactive metabolites.

• A. Both A and R are correct and R is the correct explanation of A
• B. Both A and R are correct but R is NOT the correct explanation of A
• C. A is correct but R is not correct
• D. A is not correct but R is correct

Hint:

Felbamate toxicity is a "black box" warning classic—remember "Atropaldehyde" as the reactive culprit.

Answer 1

The Correct Option is A

Step 1: Concept
Felbamate is an anticonvulsant used for severe epilepsy, but its use is limited by serious side effects.

Step 2: Meaning
Reactive metabolites are chemically unstable intermediates formed during drug metabolism that can bind to cellular proteins and cause damage.

Step 3: Analysis
Felbamate is metabolized into atropaldehyde, a highly reactive alpha,beta-unsaturated aldehyde. This metabolite is believed to be responsible for the rare but fatal cases of aplastic anemia and liver failure.

Step 4: Conclusion
Both A and R are correct, and the formation of these metabolites explains the toxicity.

Final Answer: (A)