List of top Pharmaceutical Chemistry Questions asked in GPAT

The fluoroquinolones act by:

Match the following antibodies with their correct description:

Antibody	Description
P. IgE	(i) Cross the placenta
Q. IgG	(ii) Dominant antibody produced in immune responses
R. IgM	(iii) It is found in the mother's milk
S. IgA	(iv) Responsible for autoimmune responses including allergies

Which metabolite is used to inactivate the vasico-toxic metabolite leading to hemorrhagic cystitis by alkylating agent used in the treatment of cancer

Which among the following is not used as NSAID?

Match List I with List II:

List I Name of the drug		List II Chemical class
A.	Zolpidem	I.	Cyclopyrrolone
B.	Zaleplon	II.	Benzodiazepine
C.	Zopiclone	III.	Imidazopyridine
D.	Triazolam	IV.	Pyrazolopyrimidine

Choose the correct answer from the options given below

Select the correct set of anticancer drugs that belong to “pyrimidine and related compounds”:

Which of the following is a 4th Generation Cephalosporin?

Which of the following is a third generation cephalos-Porin?

Which of the following compound would be expected to have greatest florescence?

What do you mean by Orphan Drug?

Which of the following drug used in the chemotherapy of some types of leukemia, satisfies the statements:
Statement I: It is effective orally.
Statement II: It has near 100% oral bioavailability. 
In light of the above statements, choose the correct answer from the options given below:

Which of the following is NOT an example of an mTOR inhibitor?

A patient with pheochromocytoma is undergoing surgery and has not been administered with alpha receptor blocker. If he is administered with intravenous propranolol, then which of the following effects will be evident?

Heme is ____ .

Boric acid with molecular weight 61.83 was partitioned between water and amyl alcohol at 25 °C. The amount of boric acid was determined to be 0.24 g in 250 ml of amyl alcohol and 0.32 g in 100 ml water. The partition coefficient of boric acid between water and amyl alcohol, when calculated at molar concentration for each of the solution, is:

Match the symbols in the List I with the terms used in the List II of conductance measurements, and

List I Symbols		List II Terms
A	\(\Omega^{-1}\)	I	Specific conductance
B	\(∧\)	II	Electrical conductance
C	k	III	Specific resistance
D	\(\rho\)	IV	Equivalent conductance

Choose the correct answer from the options given below:

Reason for the combination of Diphenoxylate (2.5 mg) + Atropine (0.025 mg) is to

Citric acid cycle is the final pathway during the oxidation of _______ .

Drugs ‘A’, ‘B’ and ‘C’ follow zero order, first order and second order degradation kinetics, respectively, but have the same rate constant. Which of the following statement is true in this respect:

Cottrell’s method is used for the measurement of:

Match the statements in List I with their correct answers in List II, respectively, in respect to modified 1st law of thermodynamics, and

List I		List II
A	Constant heat (q = 0)	I	Isothermal
B	Reversible process at constant temperature (dT = 0)	II	Isometric
C	Constant volume (dV = 0)	III	Adiabatic
D	Constant pressure (dP = 0)	IV	Isobar

Choose the correct answer from the options given below:

All enzymes accelerate the reaction rates by______________ .

Identify the functional groups from the below mentioned options that lead to weakening of benzoic acid:
(A):–OH
(B):–Cl
(C):–NH₂
(D):–NO₂