Question

Which of the following drug used in the chemotherapy of some types of leukemia, satisfies the statements:
Statement I: It is effective orally.
Statement II: It has near 100% oral bioavailability. 
In light of the above statements, choose the correct answer from the options given below:

• A. Asparaginase
• B. Doxorubicin
• C. Mitomycin
• D. Hydroxyurea

Answer 1

The Correct Option is A

To determine which drug used in the chemotherapy of leukemia satisfies both statements, let's analyze each option:

1. Asparaginase:
   • Statement I: Asparaginase is not typically effective orally. It is administered intravenously or intramuscularly.
   • Statement II: It does not have near 100% oral bioavailability since it is not absorbed through oral administration.
2. Doxorubicin:
   • Statement I: Doxorubicin is not effective orally. It is primarily administered intravenously.
   • Statement II: Its oral bioavailability is low and not near 100%.
3. Mitomycin:
   • Statement I: Mitomycin is administered intravenously and not effective orally.
   • Statement II: It does not have near 100% oral bioavailability.
4. Hydroxyurea:
   • Statement I: Hydroxyurea is effective orally.
   • Statement II: It has near 100% oral bioavailability, making it effective in oral administration.

Given these analyses, the correct answer should be Hydroxyurea instead of Asparaginase, as it satisfies both statements: It is effective orally and has near 100% oral bioavailability.

Therefore, the correct answer should be revised to Hydroxyurea, not Asparaginase.