Question:
Examples of BCS class III drugs are:
Examples of BCS class III drugs are:
Updated On: Jul 14, 2026
- Acyclovir, Atenolol, Captopril
- Taxol, Ellagic acid, Aspirin
- Aspirin, Paracetamol, Amoxycillin
- Chloroquine, Diltiazem, Metoprolol
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The Correct Option is A
Approach Solution - 1
The correct option is (A): Acyclovir, Atenolol, Captopril.
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Approach Solution -2
The BCS (Biopharmaceutics Classification System) sorts drugs into four classes using two properties: aqueous solubility and intestinal permeability. BCS class III drugs are highly soluble but poorly permeable, so their oral absorption is limited by how slowly they cross the gut wall rather than by how well they dissolve. Let's classify each set of drugs listed.
- Acyclovir, Atenolol, Captopril: All three are freely water soluble but cross intestinal membranes slowly because of their polar, hydrophilic structure. Acyclovir has famously low and variable oral bioavailability despite dissolving readily, and atenolol and captopril show the same solubility-good, permeability-poor pattern. This combination is the textbook set of BCS class III drugs.
- Taxol, Ellagic acid, Aspirin: Taxol (paclitaxel) is extremely poorly water soluble and crosses membranes reasonably well, placing it in BCS class II, while aspirin is highly soluble and highly permeable, placing it in class I. Mixing a class II drug with a class I drug in one group does not match the class III profile.
- Aspirin, Paracetamol, Amoxycillin: Aspirin and paracetamol are both highly soluble and highly permeable, the defining pair for BCS class I. Amoxycillin sits closer to class III because of its lower permeability, but grouping it with two class I drugs breaks the consistency needed for a class III set.
- Chloroquine, Diltiazem, Metoprolol: These three are lipophilic bases that cross membranes readily and are generally placed in BCS class I or class II depending on their solubility at different pH values. High permeability rules out class III for this group.
Only the first group, acyclovir, atenolol and captopril, consistently shows the high solubility with low permeability that defines BCS class III.
The correct answer is Acyclovir, Atenolol, Captopril.
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