List of top Biopharmaceutics and Pharmacokinetics Questions asked in GPAT

A hypertensive patient receiving a drug ‘Y’for managing BP was prescribed a tricyclic antidepressant. As a result, there was an abolition of the antihypertensive action of‘Y’. Which of the following drug could be ‘Y’?

A 70 kg woman was administered 1000 mg of the drug as i.v. bolus. After its uniform distribution in the body, the plasma concentration of the drug was found to be 50 mg/L. What is its volume of distribution?

Which of the following levels of IVIVC is represented by “the relatinship between one dissolution time point(e.g., t 50%) and one mean pharmacokinetic parameter, such as AUC, T_max or C_max”?

Under which of the following conditions in-vitro-in-vivo correlation for a drug fails?

Which of the following is true for bone tissue cell differentiation and maturation?

Which type of in-vitro-in-vivo correlation compares % drug released vs % drug absorbed?

Decrease in effective surface area available to the dissolution medium leading to a fall in the dissolution rate, may happen due to which one of the following reasons?

Match List I with List II

	List I		List II
A	When two dosage forms have equal t max	I	When their total body clearance is constant.
B	AUC values of the two analogs can be compared to measure relative bioavailability	II	Absorption rate constants are equal
C	Urinary data is valid to measure bioavailability. III. W	III	When fraction absorbed and elimination rate is constant.
D	C max is proportional to the rate of absorption	IV	Excretion of drug and/or metabolite is related to the bioavailable dose.

Choose the correct answer from the options given below:

Chitosan possesses which of the following property?

For solid oral drug products, a change in the concentration of which of the following excipients is more likely to influence the bioavailability of a drug.

For depot injections, in which drug is slowly released over weeks or months, which bioequivalence study design is used?

Method of Study Drug Distribution pattern is:

For drug substances with highly variable pharmacokinetic characteristics the following Bioequivalence study design is used

A material which is insoluble and inert and used in matrix tablet formulation is:-

When Ke is constant and Ka is larger:-

IVIVC utilizes the principles of statistical moment analysis:-

To rule out the probability of dose dumping from an oral CR dosage form, USP has included which sampling time point for in vitro dissolution test where D is normal dosing interval

(Weight in pounds/150)* Adult Dose = Child dose. The above formula is known as________in Posology

In relation to buccal and sublingual route of administration which of the following statement is incorrect