Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R).
Assertion (A) : All clinically useful local anesthetics are weak bases, and exist in equilibrium between the neutral, non-ionized, lipid soluble, and the ionized (charged), water-soluble form.
Reason (R) : All the clinically important local anesthetics are formulated as acidic solutions of hydrochloride salts which are more highly ionized, and thus water soluble.
In light of the above statements, choose the correct answer from the options given below