Question:
Which of the following drugs are non-depolarizing neuromuscular blocking agents?
(A). Atracurium
(B). Succinylcholine
(C). Pancuronium
(D). Vecuronium
Choose the correct answer from the options given below:
Which of the following drugs are non-depolarizing neuromuscular blocking agents?
(A). Atracurium
(B). Succinylcholine
(C). Pancuronium
(D). Vecuronium
Choose the correct answer from the options given below:
(A). Atracurium
(B). Succinylcholine
(C). Pancuronium
(D). Vecuronium
Choose the correct answer from the options given below:
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To easily remember the classes:
- Non-depolarizing blockers usually end in "-curium" or "-curonium" (e.g., Atracurium, Vecuronium, Pancuronium) and can be reversed using anticholinesterase agents like Neostigmine.
- Depolarizing blockers (e.g., Succinylcholine) have no pharmacological reversal agent.
- Non-depolarizing blockers usually end in "-curium" or "-curonium" (e.g., Atracurium, Vecuronium, Pancuronium) and can be reversed using anticholinesterase agents like Neostigmine.
- Depolarizing blockers (e.g., Succinylcholine) have no pharmacological reversal agent.
Updated On: Jul 14, 2026
- (A), (C) and (D) only.
- (A), (B) and (C) only.
- (A), (B), and (D) only.
- (B), (C) and (D) only.
Show Solution
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept:
Neuromuscular blocking agents (muscle relaxants) act at the nicotinic receptors ($N_m$) of the skeletal muscle neuromuscular junction.
They are classified into depolarizing and non-depolarizing (competitive) agents based on their mechanism of action.
Step 2: Detailed Explanation:
Let us classify the listed neuromuscular blockers:
- (A) Atracurium: This is a non-depolarizing neuromuscular blocker. It acts as a competitive antagonist at nicotinic acetylcholine receptors, preventing muscle depolarization. It is unique because it undergoes spontaneous degradation (Hofmann elimination) in the plasma, making it ideal for renal or hepatic impaired patients.
- (B) Succinylcholine: This is a depolarizing neuromuscular blocker. It acts as an agonist, causing persistent depolarization of the motor endplate, leading to transient muscle fasciculations followed by flaccid paralysis.
- (C) Pancuronium: This is a long-acting non-depolarizing benzylisoquinoline neuromuscular blocker.
- (D) Vecuronium: This is an intermediate-acting aminosteroid non-depolarizing neuromuscular blocker.
Therefore, Atracurium, Pancuronium, and Vecuronium are non-depolarizing agents, while Succinylcholine is depolarizing.
Step 3: Final Answer:
Thus, (A), (C), and (D) only are non-depolarizing agents, which corresponds to option (A).
Neuromuscular blocking agents (muscle relaxants) act at the nicotinic receptors ($N_m$) of the skeletal muscle neuromuscular junction.
They are classified into depolarizing and non-depolarizing (competitive) agents based on their mechanism of action.
Step 2: Detailed Explanation:
Let us classify the listed neuromuscular blockers:
- (A) Atracurium: This is a non-depolarizing neuromuscular blocker. It acts as a competitive antagonist at nicotinic acetylcholine receptors, preventing muscle depolarization. It is unique because it undergoes spontaneous degradation (Hofmann elimination) in the plasma, making it ideal for renal or hepatic impaired patients.
- (B) Succinylcholine: This is a depolarizing neuromuscular blocker. It acts as an agonist, causing persistent depolarization of the motor endplate, leading to transient muscle fasciculations followed by flaccid paralysis.
- (C) Pancuronium: This is a long-acting non-depolarizing benzylisoquinoline neuromuscular blocker.
- (D) Vecuronium: This is an intermediate-acting aminosteroid non-depolarizing neuromuscular blocker.
Therefore, Atracurium, Pancuronium, and Vecuronium are non-depolarizing agents, while Succinylcholine is depolarizing.
Step 3: Final Answer:
Thus, (A), (C), and (D) only are non-depolarizing agents, which corresponds to option (A).
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