Question:
Which of the following are associated with thrombosis?
(A) Activation of the coagulation mechanism
(B) Thrombocytopenia
(C) Formation of platelet aggregates
(D) Endothelial damage
Choose the correct answer from the options given below:
Which of the following are associated with thrombosis?
(A) Activation of the coagulation mechanism
(B) Thrombocytopenia
(C) Formation of platelet aggregates
(D) Endothelial damage
Choose the correct answer from the options given below:
(A) Activation of the coagulation mechanism
(B) Thrombocytopenia
(C) Formation of platelet aggregates
(D) Endothelial damage
Choose the correct answer from the options given below:
Show Hint
To remember Virchow's Triad of thrombosis, use the acronym "HES": Hypercoagulability (A), Endothelial injury (D), and Stasis/turbulent blood flow. Platelet aggregation (C) is the cellular bridge between these factors.
Updated On: Aug 3, 2026
- (A), (B) and (C) only.
- (A), (C) and (D) only.
- (A), (B), (C) and (D).
- (B), (C) and (D) only.
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Understanding the Concept:
Thrombosis is the formation of a solid mass (thrombus) from blood constituents within the intact vascular system during life.
Its pathogenesis is classically explained by Virchow's Triad.
Step 2: Detailed Explanation:
Let us analyze each of the factors in relation to thrombus formation:
- Endothelial damage (D): This is the most crucial factor in Virchow's Triad. Damage to the vessel wall exposes subendothelial collagen, which triggers platelet adhesion and initiates the clotting cascade.
- Activation of the coagulation mechanism (A): Hypercoagulability, caused by the activation of clotting factors, alters blood chemistry and accelerates fibrin formation, directly promoting thrombosis.
- Formation of platelet aggregates (C): Platelets adhere to the damaged site, release mediators (such as ADP and Thromboxane A2), and recruit more platelets to form a primary platelet plug, which is essential for thrombus propagation.
- Thrombocytopenia (B): This is a clinical condition characterized by an abnormally low platelet count. A deficiency in platelets impairs clotting and predisposes the body to hemorrhage (bleeding disorders), not thrombosis.
Therefore, (A), (C), and (D) are directly associated with thrombosis, while (B) is associated with bleeding.
Step 3: Final Answer:
The correct combination is (A), (C), and (D) only, corresponding to option (B).
Thrombosis is the formation of a solid mass (thrombus) from blood constituents within the intact vascular system during life.
Its pathogenesis is classically explained by Virchow's Triad.
Step 2: Detailed Explanation:
Let us analyze each of the factors in relation to thrombus formation:
- Endothelial damage (D): This is the most crucial factor in Virchow's Triad. Damage to the vessel wall exposes subendothelial collagen, which triggers platelet adhesion and initiates the clotting cascade.
- Activation of the coagulation mechanism (A): Hypercoagulability, caused by the activation of clotting factors, alters blood chemistry and accelerates fibrin formation, directly promoting thrombosis.
- Formation of platelet aggregates (C): Platelets adhere to the damaged site, release mediators (such as ADP and Thromboxane A2), and recruit more platelets to form a primary platelet plug, which is essential for thrombus propagation.
- Thrombocytopenia (B): This is a clinical condition characterized by an abnormally low platelet count. A deficiency in platelets impairs clotting and predisposes the body to hemorrhage (bleeding disorders), not thrombosis.
Therefore, (A), (C), and (D) are directly associated with thrombosis, while (B) is associated with bleeding.
Step 3: Final Answer:
The correct combination is (A), (C), and (D) only, corresponding to option (B).
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