Estrus synchronization is used to bring a group of animals into heat simultaneously. This makes planned breeding and AI possible. Prostaglandin F2α is commonly used because it causes the regression of the corpus luteum (CL) in animals that are in diestrus phase. When the CL regresses, progesterone drops and the animal returns to estrus within 2–5 days. Other protocols may use progesterone devices (like CIDR) or GnRH for timed AI programs.