Question:
Thromboxane A2 produced from
Thromboxane A2 produced from
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Remember the balancing system in hemostasis:
- Platelets produce Thromboxane A\(_2\) (promotes vasoconstriction and platelet aggregation).
- Healthy vascular endothelial cells produce Prostacyclin (PGI\(_2\)) (promotes vasodilation and inhibits platelet aggregation).
- Platelets produce Thromboxane A\(_2\) (promotes vasoconstriction and platelet aggregation).
- Healthy vascular endothelial cells produce Prostacyclin (PGI\(_2\)) (promotes vasodilation and inhibits platelet aggregation).
Updated On: Jul 8, 2026
- RBC
- Neutrophil
- Platelet
- Macrophage
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The Correct Option is C
Solution and Explanation
Step 1: Understanding the Concept:
Thromboxane A\(_2\) (TXA\(_2\)) is an eicosanoid synthesized from arachidonic acid via the cyclooxygenase (COX) pathway. It is a key mediator involved in blood vessel constriction and platelet plug formation.
Step 3: Detailed Explanation:
- Upon vascular damage, activated platelets convert arachidonic acid into prostaglandin H\(_2\) (PGH\(_2\)) using cyclooxygenase, which is subsequently converted into Thromboxane A\(_2\) by the enzyme thromboxane synthase.
- TXA\(_2\) acts as a potent local vasoconstrictor and stimulates further platelet activation and aggregation.
- Other blood cells like neutrophils, red blood cells, and macrophages secrete different inflammatory prostaglandins or leukotrienes, but do not produce significant quantities of TXA\(_2\).
Step 4: Final Answer
The primary physiological source of Thromboxane A\(_2\) is platelets.
Thromboxane A\(_2\) (TXA\(_2\)) is an eicosanoid synthesized from arachidonic acid via the cyclooxygenase (COX) pathway. It is a key mediator involved in blood vessel constriction and platelet plug formation.
Step 3: Detailed Explanation:
- Upon vascular damage, activated platelets convert arachidonic acid into prostaglandin H\(_2\) (PGH\(_2\)) using cyclooxygenase, which is subsequently converted into Thromboxane A\(_2\) by the enzyme thromboxane synthase.
- TXA\(_2\) acts as a potent local vasoconstrictor and stimulates further platelet activation and aggregation.
- Other blood cells like neutrophils, red blood cells, and macrophages secrete different inflammatory prostaglandins or leukotrienes, but do not produce significant quantities of TXA\(_2\).
Step 4: Final Answer
The primary physiological source of Thromboxane A\(_2\) is platelets.
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