Step 1: The ozone layer protects the earth from harmful ultraviolet radiation.
Step 2: Chlorofluorocarbons, commonly called CFCs, are mainly responsible for ozone layer depletion.
Step 3: \(CF_2Cl_2\) is a chlorofluorocarbon.
Step 4: In the stratosphere, CFCs release chlorine radicals under the action of UV radiation.
\[
CF_2Cl_2 \xrightarrow{UV} Cl^\cdot + \text{other products}
\]
Step 5: Chlorine radicals destroy ozone molecules repeatedly.
\[
Cl^\cdot + O_3 \rightarrow ClO^\cdot + O_2
\]
Step 6: Hence, \(CF_2Cl_2\) is mainly responsible for ozone layer depletion.
\[
\boxed{CF_2Cl_2}
\]