Question:
Which among the following represents the process of reductive deamination?
Which among the following represents the process of reductive deamination?
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In this reaction ammonia is added to alpha-ketoglutaric acid in the presence of a reducing coenzyme to form glutamic acid.
Updated On: Nov 13, 2026
\(\alpha\) - Ketoglutaric acid \(+\mathrm{NH}_{4}+\mathrm{NADPH}_{2}\rightarrow\) Glutamic acid \(+\mathrm{H}_{2}\mathrm{O}+\mathrm{NADP}\)
Glutamic acid + Oxaloacetic acid \(\rightarrow \alpha\) - Ketoglutaric acid + Aspartic acid
Glutamic acid \(+\mathrm{NH}_{4}+\) ATP \(\rightarrow \alpha -\) Glutamine + ADP
Aspartic acid \(+\mathrm{NH}_{4}+\) ATP \(\rightarrow\) Aspargine + ADP
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept
The reaction in which ammonia combines with a keto acid, with NADPH as the reductant, to give an amino acid is the reductive reaction of nitrogen assimilation.
Step 2: Analyse the options
Option with glutamic acid and oxaloacetic acid is transamination.
The options with ATP and glutamine or asparagine are amidation reactions.
Step 3: Compare the options
Only the alpha-ketoglutaric acid + \(\text{NH}_4^{+}\) + \(\text{NADPH}_2\) reaction involves the reductive step.
Final Answer:
The reaction of alpha-ketoglutaric acid with ammonia and NADPH to give glutamic acid is the required one. \[ \boxed{\text{(A) }\alpha\text{ - Ketoglutaric acid }+\text{NH}_{4}+\text{NADPH}_{2}\rightarrow\text{ Glutamic acid }+\text{H}_{2}\text{O}+\text{NADP}} \]
The reaction in which ammonia combines with a keto acid, with NADPH as the reductant, to give an amino acid is the reductive reaction of nitrogen assimilation.
Step 2: Analyse the options
Option with glutamic acid and oxaloacetic acid is transamination.
The options with ATP and glutamine or asparagine are amidation reactions.
Step 3: Compare the options
Only the alpha-ketoglutaric acid + \(\text{NH}_4^{+}\) + \(\text{NADPH}_2\) reaction involves the reductive step.
Final Answer:
The reaction of alpha-ketoglutaric acid with ammonia and NADPH to give glutamic acid is the required one. \[ \boxed{\text{(A) }\alpha\text{ - Ketoglutaric acid }+\text{NH}_{4}+\text{NADPH}_{2}\rightarrow\text{ Glutamic acid }+\text{H}_{2}\text{O}+\text{NADP}} \]
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