Question:
The eukaryotic signal recognition particle consists of ____.
The eukaryotic signal recognition particle consists of ____.
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Recall the eukaryotic SRP composition used in co-translational protein targeting to the ER.
Updated On: Jul 4, 2026
- 4 polypeptides and rRNA
- 4 polypeptides and 4.5 SL RNA
- 6 polypeptides and 7 SL RNA
- 6 polypeptides and rRNA
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The Correct Option is C
Solution and Explanation
Step 1: The signal recognition particle or SRP is a ribonucleoprotein that recognizes the signal sequence on a nascent polypeptide as it emerges from the ribosome and directs the ribosome to the endoplasmic reticulum membrane.
Step 2: In eukaryotes, the SRP is built from 6 distinct polypeptide subunits assembled onto one small RNA molecule called 7SL RNA.
Step 3: Options with rRNA or 4.5S RNA describe bacterial or partly incorrect compositions, since bacterial SRP is simpler, usually just one protein (Ffh) with 4.5S RNA. The eukaryotic version specifically has 6 polypeptides plus 7SL RNA.
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