Question

The degree of inhibition for an enzyme catalyzed reaction by an inhibitor is independent of substrate concentration. This is expected in case of

• A. Competitive inhibition
• B. Un-competitive inhibition
• C. Non-competitive inhibition
• D. Allosteric inhibition

Hint:

• Competitive → Depends on substrate
• Non-competitive → Independent of substrate

Answer 1

The Correct Option is C

Concept: Enzyme inhibition types differ based on how inhibitor interacts with enzyme and substrate:
• Competitive inhibition: Can be overcome by increasing substrate concentration.
• Non-competitive inhibition: Inhibitor binds at a different site; effect is independent of substrate concentration.
• Uncompetitive inhibition: Depends on enzyme-substrate complex.

Step 1: Analyzing each option.

• Competitive inhibition: Effect decreases with increasing substrate → Dependent.
• Uncompetitive inhibition: Depends on substrate presence → Dependent.
• Non-competitive inhibition: Inhibitor binds independently of substrate → Independent.
• Allosteric inhibition: May vary with substrate and enzyme conformation → Not strictly independent.

Step 2: Selecting the correct answer.
Only non-competitive inhibition shows inhibition independent of substrate concentration.