Question:

Statement (A) : The resolution of genetic map depends on the number of crossovers which have been scored.
Statement (B) : Genetic maps have limited accuracy as the recombination are more likely to occur at some points than at others.
In light of the above statements, choose the most appropriate answer from the options given below.

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A genetic distance of $1\text{ cM}$ is defined as a $1\%$ chance of recombination.
Because recombination rates vary, $1\text{ cM}$ can represent hundreds of thousands of base pairs in some chromosomal regions, but millions of base pairs in others, such as near the centromere.
  • Both (A) and (B) are correct.
  • Both (A) and (B) are incorrect.
  • Only (A) is correct, (B) is not correct.
  • Only (B) is correct, (A) is not correct.
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The Correct Option is A

Solution and Explanation

Step 1: Understanding the Concept:
Genetic mapping determines the relative positions of and distances between genes on a chromosome based on recombination frequencies.
The accuracy and resolution of these maps depend on both statistical sample size and biological variations in recombination rates across different regions of the genome.

Step 2: Detailed Explanation:

Let us analyze both statements individually:
Statement (A) is correct because the resolution of a genetic map is determined by the frequency of recombination events observed.
To resolve two genes that are located very close together, a large number of offspring must be screened to detect rare crossover events between them.
If the sample size is too small, no crossovers will be observed, and the genes will appear completely linked.
Therefore, scoring more crossovers increases the resolution of the genetic map.
Statement (B) is correct because recombination is not uniform across chromosomes.
Certain genomic regions, known as recombination hotspots, exhibit significantly higher rates of crossing over.
Conversely, regions near the centromere or heterochromatin are recombination coldspots where crossing over is suppressed.
Because of this variation, genetic distance (measured in centimorgans, cM) does not map linearly to physical distance (measured in base pairs, bp), which limits the physical accuracy of genetic maps.
Both statements are correct.

Step 3: Final Answer:

Both Statement (A) and Statement (B) are correct.
This corresponds to Option (A).
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