Step 1: Concept
Blood pressure is the force exerted by circulating blood against the walls of the body's arteries.
Step 2: Meaning
It is mathematically defined by the relationship between the volume of blood pumped and the resistance it encounters.
Step 3: Analysis
The primary equation for blood pressure is $BP = CO \times TPR$. Cardiac output ($CO$) is the volume of blood pumped per minute, and total peripheral resistance ($TPR$) is the resistance in the circulatory system.
Step 4: Conclusion
Therefore, Cardiac output and total peripheral resistance are the two main determining factors of blood pressure.
Final Answer: (C)