Question

Match List I with List II

List I		List II
A	Down’s syndrome	I	11th chormosome
B	α-Thalassemia	II	‘X’ chromosome
C	β-Thalassemia	III	21st chromosome
D	Klinefelter’s syndrome	IV	16th chromosome

Choose the correct answer from the options given below:

• A. A-I, B-II, C-III, D-IV
• B. A-II, B-III, C-IV, D-I
• C. A-III, B-IV, C-I, D-II
• D. A-IV, B-I, C-II, D-III

Answer 1

The Correct Option is C

The problem involves matching conditions related to chromosomal locations with their correct descriptions, providing relationships between genetic disorders and their associated chromosomes.

Here's how the matches are established:

• Down’s syndrome is known to be caused by the presence of an extra chromosome 21 (Trisomy 21). Therefore, it matches with III - 21^st chromosome.
• α-Thalassemia is a condition that involves the 16^th chromosome, where deletions affect the production of alpha globin chains. Therefore, it matches with IV - 16^th chromosome.
• β-Thalassemia is linked with mutations in the β-globin gene on the 11^th chromosome. Hence, it matches with I - 11^th chromosome.
• Klinefelter’s syndrome involves an additional 'X' chromosome, resulting in a karyotype of 47,XXY. Thus, it matches with II - ‘X’ chromosome.

Based on these matches, the correct arrangement is as follows:

A	III
B	IV
C	I
D	II

The correct answer is: A-III, B-IV, C-I, D-II.

Answer 2

A. Down’s syndrome → Trisomy of 21st chromosome → III.

B. α-Thalassemia → Linked to 16th chromosome → IV.

C. β-Thalassemia → Linked to 11th chromosome → I.

D. Klinefelter’s syndrome → Extra X chromosome in males → II.

Thus, the correct answer is (3) A-III, B-IV, C-I, D-II.