Question

Match List-I with List-II
List-I & List-II
(A) Widal test & (I) Tuberculosis
(B) Dick test & (II) Scarlet fever
(C) Mantoux test & (III) Typhoid
(D) Schick test & (IV) Diphtheria

Choose the correct answer from the options given below:

• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (IV), (B) - (II), (D) - (III), (C) - (I)
• (A) - (II), (B) - (I), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (II), (C) - (I), (D) - (IV)

Hint:

To remember these:
- Widal = Typhoid (classic blood test).
- Dick = Scarlet fever (Streptococcus toxin).
- Mantoux = Tuberculosis (PPD skin reaction).
- Schick = Diphtheria (susceptibility check).

Answer 1

The Correct Option is D

Step 1: Understanding the Concept:
Diagnostic immunology and microbiology employ specific in-vitro and in-vivo tests to identify pathogens or determine host susceptibility to bacterial toxins.
Detailed Explanation:
Let us analyze and match each test in List-I with its corresponding disease in List-II:
1. (A) Widal test matches with (III) Typhoid:
The Widal test is a classic serological agglutination assay.
It detects diagnostic antibodies against the lipopolysaccharide somatic (O) and flagellar (H) antigens of Salmonella enterica serovar Typhi in the serum of patients suspected of having typhoid fever.
2. (B) Dick test matches with (II) Scarlet fever:
The Dick test is an in-vivo skin test used to determine a patient's susceptibility or immunity to scarlet fever.
The test involves injecting a small amount of erythrogenic toxin, produced by Streptococcus pyogenes, intradermally.
A localized red reaction indicates susceptibility, while no reaction indicates neutralizing antibodies are present.
3. (C) Mantoux test matches with (I) Tuberculosis:
The Mantoux test (tuberculin skin test) is used to screen for infection by Mycobacterium tuberculosis.
It involves intradermal injection of Purified Protein Derivative (PPD).
The development of a delayed-type hypersensitivity reaction (measured by the diameter of induration) after 48 to 72 hours indicates previous exposure or active infection.
4. (D) Schick test matches with (IV) Diphtheria:
The Schick test is a skin test used to determine susceptibility to Corynebacterium diphtheriae toxin.
Intradermal injection of a diluted diphtheria toxin causes local inflammation in individuals lacking protective antitoxin antibodies.

Step 2: Final Answer:
The correct matching is (A) - (III), (B) - (II), (C) - (I), (D) - (IV).