Question

Match List-I with List-II:

Choose the correct answer from the options given below:

• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (I), (B) - (III), (C) - (II), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Remember the easy key associations:
- \(\beta\) = base repair (B \(\rightarrow\) II).
- \(\gamma\) = generator of mitochondrial DNA (C \(\rightarrow\) III).
These two relationships instantly narrow down the matching choices.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
Eukaryotic cells contain multiple specialized DNA polymerases classified by Greek letters, each with specific cellular roles in nuclear replication, mitochondrial replication, or DNA repair.

Step 2: Detailed Explanation:
- DNA polymerase \(\alpha\) (A): Exists in a complex with primase to initiate replication. It is responsible for initiating replication on both strands and performing the initial gap filling and synthesis on the lagging strand (I).
- DNA polymerase \(\beta\) (B): Primarily functions in base excision repair (BER) and gap-filling synthesis during DNA repair pathways (II).
- DNA polymerase \(\gamma\) (C): Located exclusively in the mitochondria, where it replicates and repairs mitochondrial DNA (III).
- DNA polymerase \(\delta\) (D): Serves as the primary replicative polymerase for leading and lagging strand synthesis (IV).

Step 3: Final Answer:
The correct matching sequence is (A) - (I), (B) - (II), (C) - (III), (D) - (IV), corresponding to option (A).