Question

Fluid mosaic model of cell membrane is given by

• A. Singer and Nicolson
• B. De Duve
• C. Koshland
• D. Emil Fisher

Hint:

Keep the key timeline in mind: Singer and Nicolson (1972) proposed the Fluid Mosaic Model, which replaced older, rigid bilayer models like the Davson-Danielli sandwich model.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
The structural layout of biological membranes must explain both their stable barrier function and their dynamic fluidity.

Step 2: Detailed Explanation:
1. The Fluid Mosaic Model describes the cell membrane as a double layer of lipids (bilayer) in which various protein molecules are embedded.
2. This model was proposed by S. J. Singer and Garth L. Nicolson in 1972.
3. The "fluid" part represents the lateral mobility of the lipid molecules, while the "mosaic" part describes the heterogeneous distribution of membrane proteins within the bilayer.
Christian de Duve discovered lysosomes, Daniel Koshland proposed the induced-fit model of enzyme substrate binding, and Emil Fischer proposed the lock-and-key model of enzyme action.

Step 3: Final Answer:
The correct option is 1, which corresponds to Singer and Nicolson.